Helping The others Realize The Advantages Of ceesdekker.net
Helping The others Realize The Advantages Of ceesdekker.net
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Employing solitary-molecule optical and AFM imaging and force-spectroscopy techniques, we request to unravel the mechanistic areas of the construction and dynamics of chromosomes. Our study pursuits incorporate:
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Dynamics of initiation, termination and reinitiation of DNA translocation through the motor protein EcoR124I
Non-equilibrium folding of specific DNA molecules recaptured as many as one thousand moments in the stable condition nanopore
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Our research ranges from the biophysics of DNA to synthetic cells and beyond. Make sure you have a look beneath in the spectrum of our present projects.
‘Initially we looked at Organic systems using a Bodily view and acted on the basis on the applications we knew. It took a couple of years ahead of we begun Operating far more on the large Organic challenges. I then started to get in touch with it nanobiology, a expression that didn't exist at enough time.
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Understanding fundamental procedures regulating the spatial and dynamic organisation of the DNA in live cells.
Dekker began his research on one carbon nanotubes in 1993 when he create a brand new line of investigate to review electrical transport by solitary natural and organic molecules involving nanoelectrodes. In 1996 a breakthrough was realized with carbon nanotubes. This was obtained in a very collaboration With all the team of Nobel laureate Richard Smalley. STM and nanolithography tactics were accustomed to demonstrate that these nanotubes are quantum wires at The one-molecule degree, with outstanding Bodily properties.
Considering the fact that 2000 he moved to solitary-molecule biophysics and nanobiology, with research from scientific tests of DNA loop extrusion and supercoiling to DNA translocation by means of nanopores. More not long ago his analysis ceesdekker has centered on learning chromatin composition and cell division with microbes on chip, although he is also aiming to ultimately Make synthetic cells from the bottom up.
Cees Dekker is Distinguished College Professor at TU Delft. Properly trained to be a physicist, he pioneered nanotechnology with many discoveries on carbon nanotubes in the 1990s. Since 2000, he moved to one-molecule biophysics and nanobiology. His present-day investigate concentrates on (i) nanopores for protein sequencing; (ii) chromosome framework, specifically SMC motor protein; and (iii) developing a residing synthetic cell from lifeless molecules. Dekker is an elected member of the KNAW and fellow into the APS as well as IOP.
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2013, managed shaping of Dwell bacterial cells into arbitrary styles; and discovery of spontaneous fluctuations inside the handedness of histone tetrasomes